Serving as the prequel to the Predator movies, it explores the origins of the fearsome extraterrestrial beings in the Predator franchise and explains their emergence on Earth.
The story revolves around a young Comanche woman, Naru, who is striving to prove herself as a hunter. She finds herself having to protect her people from a vicious, humanoid alien that hunts humans for sport, as well as from French fur traders who are destroying the buffalo they rely on for survival.